A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials

We propose a theoretical model for pfDHFR-TS, which includes the 55 aminoacid residues ignored in the crystallographic model. The electrostatic potential calculation on the model surface revealed a continuous positive potential region between the two active sites, suggesting an optimized mechanism f...

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Hauptverfasser:	França Tanos C. C., Medeiros André L. R. de, Santos Edison C. P. dos, Santos-Filho Osvaldo A., Figueroa-Villar José D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Sociedade Brasileira de Química 2004-01-01
Schriftenreihe:	Journal of the Brazilian Chemical Society
Schlagworte:	malaria homology modeling DHFR-TS optimized substrate transport Plasmodium falciparum
Online-Zugang:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532004000300019
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