Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells

Abstract Expression of the PD-1 protein by tumor cells is relatively common and has been shown to exert proliferation-inhibitory effects across various tumor types, including T-cell malignancies, non-small cell lung cancer, and colon cancer. However, harnessing this tumor suppressor pathway is chall...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Fangxin Zhao, Xuan Zhang, Ying Tang, Hongxin Yang, Haiting Pan, Beibei Li, Riwen An, Wu Geyemuri, Chao Yang, Fang Wan, Jianqiang Wu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2025-04-01
Rangatū:	Scientific Reports
Ngā marau:	PD-1/PD-L1 TCR-T MAGE-C2 Cancer Immunotherapy
Urunga tuihono:	https://doi.org/10.1038/s41598-025-92209-z
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!