Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice

Peroxisomes are dynamic organelles that play a crucial role in cellular metabolism, particularly in fatty acid degradation, cholesterol homeostasis and reactive oxygen species metabolism. Their dysfunction is associated with severe neurological disorders, including Zellweger spectrum disorders (ZSD)...

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Bibliographic Details

Main Authors:	Tanja Eberhart, Khanichi N. Charles, Brenda Salumbides-Torres, Nia Price, Steven J. Fliesler, Phyllis L. Faust, Werner J. Kovacs
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	brain central nervous system cholesterol fatty acids myelination peroxisomes
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2026.1636268/full
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