Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed that...

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Detalhes bibliográficos

Principais autores:	Sophie Ayciriex, Fathia Djelti, Sandro Alves, Anne Regazzetti, Mathieu Gaudin, Jennifer Varin, Dominique Langui, Ivan Bièche, Eloise Hudry, Delphine Dargère, Patrick Aubourg, Nicolas Auzeil, Olivier Laprévote, Nathalie Cartier
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-07-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	neurodegeneration gene silencing Cyp46a1 cholesterol lipidomics lipid dysregulation
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00211/full
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