RSK3 switches cell fate: from stress-induced senescence to malignant progression

Abstract Background TGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and epithelial-mesenchymal transition (EMT) in normal epithelial cells. During carcinogenesis cells lose the ability to undergo senescence in response to TGFβ...

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Главные авторы:	Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2023-11-01
Серии:	Journal of Experimental & Clinical Cancer Research
Предметы:	Cellular senescence Epithelial-mesenchymal transition TGFβ Breast tumor
Online-ссылка:	https://doi.org/10.1186/s13046-023-02909-5
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