CDKN2A homozygous deletions and TSC2 somatic mutations in metastatic pancreatic neuroendocrine tumors

Abstract Despite improvements in the molecular profiling of pancreatic neuroendocrine tumors (PanNETs), predicting their clinical behavior and response to specific therapies remains challenging. We sought to elucidate the molecular basis underlying the broad phenotypic variations in these neoplasms...

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Principais autores:	Tito Teles Jesus, Lorenzo Ferrando, Lia Rodrigues, Rui Sousa Martins, Luís Cardoso, José Manuel Lopes, Paula Soares, Arnaud Da Cruz Paula, João Vinagre
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Series:	npj Precision Oncology
Acceso en liña:	https://doi.org/10.1038/s41698-025-01210-2
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