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High-resolution description of antibody heavy-chain repertoires in humans.

Antibodies' protective, pathological, and therapeutic properties result from their considerable diversity. This diversity is almost limitless in potential, but actual diversity is still poorly understood. Here we use deep sequencing to characterize the diversity of the heavy-chain CDR3 region, the m...

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Hlavní autoři: Ramy Arnaout, William Lee, Patrick Cahill, Tracey Honan, Todd Sparrow, Michael Weiand, Chad Nusbaum, Klaus Rajewsky, Sergei B Koralov
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2011-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3150326?pdf=render
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