Defining alteration in bone marrow mesenchymal stem cells (MSC) from acute myeloid leukemia and exploring cultured MSC-conditioned media as a novel anti-leukemia therapy agent

Abstract Background Bone marrow-resident mesenchymal stem cells (BM-MSC) often play a role in acute myeloid leukemia (AML) progression and drug resistance by exerting immunomodulatory effects on cellular as well as soluble milieu. The current study aimed to understand the dynamic interplay between A...

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Bibliografiske detaljer

Principais autores:	Manasi Nagare, Monalisa Sahoo, Manju Sengar, Sachin Punatar, Navin Khattry, Anant Gokarn, Bhausaheb Bagal, Hasmukh Jain, Sumeet Mirgh, Sridhar Epari, Tanuja Shet, Trupti Pradhan, Shweta Shirsat, Madan Barkume, Caroline Mathen, Poonam Gera, Rohit Kumar Verma, Elveera Saldanha, Pratik Chandrani, Jitendra Gawde, Shubhada Chiplunkar, Jyoti Kode
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2026-02-01
Serier:	Cancer Immunology, Immunotherapy
Fag:	Acute myeloid leukemia Bone marrow microenvironment Mesenchymal stem cells Patient-derived MSC-conditioned media In vivo anticancer efficacy Inflammasome pathway regulation
Online adgang:	https://doi.org/10.1007/s00262-025-04262-2
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