Pro-inflammatory conditions promote neuronal damage mediated by Amyloid Precursor Protein and decrease its phagocytosis and degradation by microglial cells in culture

Aberrant handling of Amyloid Precursor Protein (APP) and β-amyloid (Aβ), glial activation and inflammation are key events in Alzheimer’s disease. We set out to determine the role of inflammation on microglial reactivity against APP. We studied microglia-mediated neurotoxicity, uptake and degradation...

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Auteurs principaux:	Rommy von Bernhardi, Gigliola Ramírez, Rodrigo Toro, Jaime Eugenín
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2007-04-01
Collection:	Neurobiology of Disease
Sujets:	Alzheimer’s disease APP processing Astrocytes β-amyloid Glia Inflammation
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0969996106003196
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