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Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations

Abstract Background Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the standard lipid measurements, apolipoprotein concentrations provide added awareness of the burden of circulating lipoproteins. Wh...

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Principais autores: Niina Sandholm, Ronja Hotakainen, Jani K. Haukka, Fanny Jansson Sigfrids, Emma H. Dahlström, Anni A. Antikainen, Erkka Valo, Anna Syreeni, Elina Kilpeläinen, Anastasia Kytölä, Aarno Palotie, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop, on behalf of the FinnDiane Study Group
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-11-01
Serier:Genome Medicine
Fag:
Apolipoprotein A1
Apolipoprotein C-III
Whole-exome sequencing
Lipidomics
LIPC
APOB
Online adgang:https://doi.org/10.1186/s13073-022-01135-6
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