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Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker

Abstract Retinal melanosome/melanolipofuscin-containing cells (MCCs), clinically visible as hyperreflective foci (HRF) and a highly predictive imaging biomarker for the progression of age-related macular degeneration (AMD), are widely believed to be migrating retinal pigment epithelial (RPE) cells....

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Autori principali: Sebastien Augustin, Marion Lam, Sophie Lavalette, Anna Verschueren, Frédéric Blond, Valérie Forster, Lauriane Przegralek, Zhiguo He, Daniel Lewandowski, Alexis-Pierre Bemelmans, Serge Picaud, José-Alain Sahel, Thibaud Mathis, Michel Paques, Gilles Thuret, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-02-01
Serie:Journal of Neuroinflammation
Soggetti:
Age-related macular degeneration
Macrophage
CD47
Neuroinflammation
Accesso online:https://doi.org/10.1186/s12974-023-02699-9
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