The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection

Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulat...

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Bibliografiske detaljer

Principais autores:	Deepika Vasudevan, Nicholas K. Clark, Jessica Sam, Victoria C. Cotham, Beatrix Ueberheide, Michael T. Marr, II, Hyung Don Ryoo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2017-11-01
Serier:	Cell Reports
Fag:	antimicrobial peptides GCN2 ATF4 4E-BP mRNA translation innate immunity 5' UTR internal ribosome entry site
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124717315760
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