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Perturbation of Circulating Inflammatory Proteins Mediates the Relationship Between Cholecystectomy and Nonalcoholic Fatty Liver Disease: A Multivariate and Mediation Mendelian Randomization Study

ABSTRACT Background and Aims Observational studies suggest a link between cholecystectomy and nonalcoholic fatty liver disease (NAFLD), but whether cholecystectomy is an independent causal risk factor and the underlying mechanisms remain unclear. Inflammation, a key driver of NAFLD, is a potential m...

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Principais autores: Cong Chen, Jinming Chen, Jilin Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-10-01
coleção:Health Science Reports
Assuntos:
causal relationship
cholecystectomy
circulating inflammatory proteins
Mendelian randomization
nonalcoholic fatty liver disease
TNFRSF9
Acesso em linha:https://doi.org/10.1002/hsr2.71303
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