mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker's yeast 60 new mlh3 alleles. Five...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Najla Al-Sweel, Vandana Raghavan, Abhishek Dutta, V P Ajith, Luigi Di Vietro, Nabila Khondakar, Carol M Manhart, Jennifer A Surtees, K T Nishant, Eric Alani
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2017-08-01
Schriftenreihe:	PLoS Genetics
Online-Zugang:	http://europepmc.org/articles/PMC5578695?pdf=render
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