Repurposing DrugBank compounds as potential Plasmodium falciparum class 1a aminoacyl tRNA synthetase multi-stage pan-inhibitors with a specific focus on mitomycin

Plasmodium falciparum aminoacyl tRNA synthetases (PfaaRSs) are potent antimalarial targets essential for proteome fidelity and overall parasite survival in every stage of the parasite's life cycle. So far, some of these proteins have been singly targeted yielding inhibitor compounds that have been l...

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Detalhes bibliográficos

Principais autores:	Fisayo Olotu, Mariscal Brice Tchatat Tali, Curtis Chepsiror, Olivier Sheik Amamuddy, Fabrice Fekam Boyom, Özlem Tastan Bishop
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-08-01
coleção:	International Journal for Parasitology: Drugs and Drug Resistance
Assuntos:	Plasmodium falciparum tRNA synthetases Structure-based drug discovery Malaria Mitomycin Pan-inhibition
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211320724000290
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