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CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

IntroductionRegulatory T-cells (Tregs) are characterized by the expression of Foxp3, a master regulator involved in the development and function of Tregs. Foxp3 expression is dependent on activity of the Treg specific demethylated site (TSDR), which contains a CREB binding site. We aimed to find out...

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Autors principals: Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Saskia Schulz, Thomas Look, Tannaz Goodarzi, Tim Clarner, Miriam Scheld, Markus Kipp, Eva Verjans, Svenja Böll, Christopher Neullens, Ivan Costa, Zhijian Li, Lin Gan, Bernd Denecke, Angela Schippers, Stefan Floess, Jochen Huehn, Edgar Schmitt, Tobias Bopp, Hermann Wasmuth, Ron Winograd, Rudi Beyaert, Bart Lambrecht, Martin Zenke, Norbert Wagner, Kim Ohl, Klaus Tenbrock
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2025-07-01
Col·lecció:Frontiers in Immunology
Matèries:
IL-33
ST2
Foxp3
IL-10
CREB
CREM
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601008/full
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