Cyclization-activated Prodrugs
Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier m...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI AG
2007-11-01
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| Series: | Molecules |
| Assuntos: | |
| Acceso en liña: | http://www.mdpi.com/1420-3049/12/11/2484/ |
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