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Evolving Therapeutic Landscape of ROS1-Positive Non-Small Cell Lung Cancer: An Updated Review

<i>ROS1</i> gene rearrangements define a distinct molecular subtype of non-small cell lung cancer (NSCLC), occurring in approximately 2% of cases and frequently associated with younger age, non-smoker status, and a high incidence of brain metastases. The discovery of ROS1 as an oncogenic driver has...

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Main Authors: Hervé Bischoff, Sébastien Gendarme, Laura Somme, Christos Chouaid, Roland Schott
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-11-01
Series:Current Oncology
Subjects:
ROS1
non-small cell lung cancer
tyrosine kinase inhibitor
resistance mutations
brain metastases
targeted therapy
Online Access:https://www.mdpi.com/1718-7729/32/11/626
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