MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways

Microglial activation and sustained inflammation in the brain can lead to neuronal damage. Hence, limiting microglial activation and brain inflammation is a good therapeutic strategy for inflammatory-associated central nervous disease. MiR-146a is a promising therapeutic microRNA, since it can negat...

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Hlavní autoři:	Guang-Jie Liu, Qing-Rong Zhang, Xuan Gao, Han Wang, Tao Tao, Yong-Yue Gao, Yan Zhou, Xiang-Xin Chen, Wei Li, Chun-Hua Hang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-04-01
Edice:	Frontiers in Neuroscience
Témata:	subarachnoid hemorrhage microglial polarization miR-146a neuro-inflammation TRAF6 IRAK1
On-line přístup:	https://www.frontiersin.org/article/10.3389/fnins.2020.00311/full
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