Roles of lactate and lactylation in tumor immune suppression and drug resistance
Metabolic reprogramming is a hallmark of cancer, with excessive lactate accumulation driven by aerobic glycolysis profoundly reshaping the tumor microenvironment (TME). Beyond being a metabolic by-product, lactate acts as a signaling metabolite and epigenetic regulator that promotes immune suppressi...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2026-05-01
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| Serier: | Frontiers in Immunology |
| Fag: | |
| Online adgang: | https://www.frontiersin.org/articles/10.3389/fimmu.2026.1836534/full |
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