Pan cohort immune biomarker of CD8 lymphocyte activation enabling HGSOC outcome prediction and treatment response

Abstract Background High-grade serous ovarian cancer (HGSOC) exhibits poor prognosis due to late diagnosis, chemoresistance, and limited responses to immune checkpoint inhibitors. Although tumor‐infiltrating CD8+ T cells correlate with improved survival, current prognostic models remain inadequate....

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主要な著者:	Xinkui Liu, Zhen Zhang, Bin Wang, Liping Qin, Nannan Fan, Ruohan Wang, Xiaoyan Yu, Qiaoqiao Han, Zihan Lu, Siambi Kikete, Feifei Shi, Chu Chu, Yunhong Zhang, Liangzhong Niu, Ran Wei, Jiarui Wu, Xia Li
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer 2025-12-01
シリーズ:	Discover Oncology
主題:	High-grade serous ovarian cancer Tumor environment CD8+ T cell Machine learning
オンライン･アクセス:	https://doi.org/10.1007/s12672-025-04363-5
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