Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS. Animal studies suggested that complement activation plays an important role in the pathogen...

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Principais autores:	Stephanie L. Savelli, Robert A. S. Roubey, Kathryn J. Kitzmiller, Danlei Zhou, Haikady N. Nagaraja, Evan Mulvihill, Fatima Barbar-Smiley, Stacy P. Ardoin, Yee Ling Wu, Chack-Yung Yu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-05-01
coleção:	Frontiers in Immunology
Assuntos:	C3 and C4 C4A and C4B Copy number variation Factor H Lupus anticoagulant Mannan binding lectin
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00885/full
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