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Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist

Background: Roflumilast is an option for treating patients with severe COPD and frequent exacerbations despite optimal therapy with inhaled drugs. The present study focused on whether the phosphodiesterase (PDE) 4 inhibitor roflumilast and its active metabolite roflumilast N-oxide affect the release...

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Principais autores: Hélène Salvator, Amparo Buenestado, Marion Brollo, Emmanuel Naline, Tatiana Victoni, Elisabeth Longchamp, Hermann Tenor, Stanislas Grassin-Delyle, Philippe Devillier
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-12-01
Serier:Frontiers in Pharmacology
Fag:
roflumilast
beta-2-adrenoceptor agonist
human bronchus
cytokine
lipopolysaccharide
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2020.598702/full
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