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Andrographolide and 4-Phenylbutyric Acid Administration Increase the Expression of Antimicrobial Peptides Beta-Defensin-1 and Cathelicidin and Reduce Mortality in Murine Sepsis

Antibiotic resistance is a global threat and requires the search for new treatment strategies. Natural antimicrobial peptides (AMPs) have pronounced antibacterial, antiviral, antifungal, and antitumor activity. AMPs’ clinical use is complicated by the high synthesis costs and rapid proteolytic degra...

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Principais autores: Albert Bolatchiev, Vladimir Baturin, Elizaveta Bolatchieva
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-11-01
coleção:Antibiotics
Assuntos:
antimicrobial peptide
antibiotic resistance
andrographolide
4-phenylbutyric acid
defensin
cathelicidin
Acesso em linha:https://www.mdpi.com/2079-6382/11/11/1629
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