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Detecting Protein-DNA binding in single molecules using antibody guided methylation

Abstract Characterization of DNA binding sites for specific proteins is of fundamental importance in molecular biology. It is commonly addressed experimentally by chromatin immunoprecipitation and sequencing (ChIP-seq) of bulk samples (103-107 cells). We have developed an alternative method that use...

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Bibliografische gegevens
Hoofdauteurs: Apoorva Thatavarty, Naor Sagy, Michael R. Erdos, Isac Lee, Jared T. Simpson, Winston Timp, Francis S. Collins, Daniel Z. Bar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2025-07-01
Reeks:Epigenetics & Chromatin
Online toegang:https://doi.org/10.1186/s13072-025-00602-9
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