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Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages

<p>Abstract</p> <p>Background</p> <p>RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ideal for transduction of such inhibitory RNAs into hemat...

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Hoofdauteurs: Rossi John, Remling Leila, Li Ming-Jie, Banerjea Akhil, Akkina Ramesh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2004-12-01
Reeks:AIDS Research and Therapy
Onderwerpen:
AIDS gene therapy
HIV tar decoy
CCR5 ribozyme
SCID-hu mice
Lentiviral vectors
HIV aptamers
CD34 cells
Online toegang:http://www.aidsrestherapy.com/content/1/1/2
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