Development of a four-gene host signature for paucibacillary TB among symptomatic individuals with sputum Xpert MTB/RIF Ultra very low and trace results

Objectives: The Xpert MTB/RIF Ultra (Ultra) assay is widely used to diagnose pulmonary tuberculosis (TB), but “very low” or “trace” results may reflect either paucibacillary TB or TB-negative disease, complicating clinical decision-making. We evaluated host transcriptomic signatures to identify cult...

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Bibliografische gegevens

Hoofdauteurs:	Kattya Lopez, Robert Reiss, Vaishnavi Kaipilyawar, Arthur VanValkenburg, Xutao Wang, Nisha Modi, Emily Hennig, Aanchal Wats, Christie Eichberg, Lydia Nakiyingi, Chad Centner, Kimberly McCarthy, Jerrold J. Ellner, David Alland, Susan E. Dorman, W. Evan Johnson, Yingda L. Xie, Padmini Salgame
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2026-08-01
Reeks:	International Journal of Infectious Diseases
Onderwerpen:	Biomarker Tuberculosis Xpert MTB/RIF Ultra
Online toegang:	http://www.sciencedirect.com/science/article/pii/S120197122600398X
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