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Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

This present work is designed to evaluate the anti-diabetic potential of 22 ginsenosides via the inhibition against rat lens aldose reductase (RLAR), and human recombinant aldose reductase (HRAR), using <sub>DL</sub>-glyceraldehyde as a substrate. Among the ginsenosides tested, ginsenoside Rh2, (20<...

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Principais autores: Md Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan, M. Mizanur Rahman, Seong Kyu Park, Mun Seog Chang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-03-01
coleção:Molecules
Assuntos:
ginsenosides
diabetic complication
aldose reductase
enzyme kinetics
molecular docking
sorbitol accumulation
Acesso em linha:https://www.mdpi.com/1420-3049/27/7/2134
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