IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

Abstract Background The endoplasmic reticulum (ER) is responsible for the control of correct protein folding and protein function which is crucial for cell survival. However, under pathological conditions, such as hypoxia–ischemia (HI), there is an accumulation of unfolded proteins thereby triggerin...

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Autores principales:	Di Chen, Brandon J. Dixon, Desislava M. Doycheva, Bo Li, Yang Zhang, Qin Hu, Yue He, Zongduo Guo, Derek Nowrangi, Jerry Flores, Valery Filippov, John H. Zhang, Jiping Tang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2018-02-01
Colección:	Journal of Neuroinflammation
Materias:	Hypoxia–ischemia IRE1α MicroRNA-17 (miR-17) Neonatal Nod-like receptor protein 3 (NLRP3) Thioredoxin-interacting protein (TXNIP)
Acceso en línea:	http://link.springer.com/article/10.1186/s12974-018-1077-9
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