The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase-separated molecular ‘sponges’, stabilized by quinary (transient and weak) interactions, control proteins involved in numerous biological...

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Bibliografische Detailangaben

Hauptverfasser:	Sébastien Lyonnais, S. Kashif Sadiq, Cristina Lorca-Oró, Laure Dufau, Sara Nieto-Marquez, Tuixent Escribà, Natalia Gabrielli, Xiao Tan, Mohamed Ouizougun-Oubari, Josephine Okoronkwo, Michèle Reboud-Ravaux, José Maria Gatell, Roland Marquet, Jean-Christophe Paillart, Andreas Meyerhans, Carine Tisné, Robert J. Gorelick, Gilles Mirambeau
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-11-01
Schriftenreihe:	Viruses
Schlagworte:	HIV-1 nucleocapsid RNA liquid–liquid phase separation protease molecular dynamics
Online-Zugang:	https://www.mdpi.com/1999-4915/13/11/2312
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