Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort

Background: Dynamic contrast-enhanced (DCE) MRI using intravenous injection of gadolinium-based contrast agents (GBCAs) is commonly used for imaging blood-brain barrier (BBB) permeability. Water is an alternative endogenous tracer with limited exchange rate across the BBB. A direct comparison betwee...

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Principais autores:	Xingfeng Shao, Kay Jann, Samantha J. Ma, Lirong Yan, Axel Montagne, John M. Ringman, Berislav V. Zlokovic, Danny J. J. Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-11-01
coleção:	Frontiers in Neuroscience
Assuntos:	blood-brain barrier (BBB) water exchange rate permeability arterial spin labeling (ASL) white matter hyperintensity (WMH) cerebral small vessel disease (CSVD)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2020.571480/full
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