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TGF-β1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3

Objective: Systemic sclerosis (SSc) is a complex autoimmune disease resulting in fibrosis of skin and internal organs. Despite progress in treatment, SSc carries high mortality due to organ fibrosis. This study aimed to identify a potential antifibrotic therapeutic for the treatment of SSc. Methods:...

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Autori principali: Zhaopeng Chen, Yinru Lin, Yayi Huang, Zhixian Chen, Yao Gong, Zhiduo Hou, Ling Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-12-01
Serie:Journal of Translational Autoimmunity
Soggetti:
P4HA3
Prolyl 4-hydroxylases
Scleroderma
SFRP2
Systemic sclerosis
Accesso online:http://www.sciencedirect.com/science/article/pii/S2589909025000589
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