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Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases

Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation. Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from t...

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Autors principals: Huitang Qi, Xi Jiang, Yi Ding, Tian Liu, Qing Yang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021-04-01
Col·lecció:Frontiers in Molecular Biosciences
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fmolb.2021.640356/full
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