Cardiac Safety of Intranasal Chlorpheniramine: An Exposure-Based Risk Assessment

<b>Background:</b> H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and torsades de pointes (TdP). These effects a...

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Hlavní autoři:	César Alas-Pineda, Dennis J. Pavón-Varela, Kristhel Gaitán-Zambrano, Gustavo Ferrer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-04-01
Edice:	Pharmaceuticals
Témata:	chlorpheniramine intranasal antihistamines cardiotoxicity QT prolongation hERG pharmacokinetics
On-line přístup:	https://www.mdpi.com/1424-8247/19/5/670
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