Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling

Stenodactylin, a highly toxic type 2 ribosome-inactivating protein purified from the caudex of Adenia stenodactyla Harms, is a potential anticancer drug candidate. Previous studies demonstrated that stenodactylin induces apoptosis and necroptosis in treated cells, involving the production of reactiv...

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Detalhes bibliográficos

Principais autores:	Daniele Mercatelli, Massimo Bortolotti, Vibeke Andresen, André Sulen, Letizia Polito, Bjørn Tore Gjertsen, Andrea Bolognesi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-05-01
Colecção:	Frontiers in Pharmacology
Assuntos:	acute myeloid leukemia apoptosis plant toxins ribosome-inactivating protein stenodactylin toxic lectins
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2020.00630/full
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