Orthosteric–allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer

Introduction: Phosphatidylinositol 5-phosphate 4-kinase type II gamma (PI5P4Kγ) has emerged as a promising therapeutic target in oncology due to its key role in cancer progression. However, currently available inhibitors targeting either the orthosteric or allosteric sites of PI5P4Kγ suffer from lim...

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Hlavní autoři:	Liang Xiong, Lei Tang, Wenfeng Zhao, Rongtao Wang, Cheng Cheng, Daoping Wang, Yechun Xu, Yanhua Fan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-06-01
Edice:	Journal of Advanced Research
Témata:	PI5P4Kγ Orthosteric-allosteric dual inhibitors of PI5P4Kγ NSCLC Cell apoptosis Metastasis
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2090123225007283
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