Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma

IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS). Here we assessed the ability of cyclic AMP-dependent protein kinase (PKA) signalin...

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Hlavní autoři:	Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-04-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	cyclic AMP-dependent protein kinase cochlea spiral ganglion neuron auditory nerve synapse regeneration
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2024.1363219/full
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