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Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9

Efficient gene transfer to muscle stem cells (satellite cells) has not been achieved despite broad transduction of skeletal muscle by systemically administered adeno-associated virus serotype 2/9 (AAV-9) in mice. We hypothesized that cellular migration during fetal development would make satellite c...

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Principais autores: David H Stitelman, Tim Brazelton, Archana Bora, Jeremy Traas, Demetri Merianos, Maria Limberis, Marcus Davey, Alan W Flake
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050116301085
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