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Alterations in the gut microbiome and metabolism profiles reveal the possible molecular mechanism of renal injury induced by hyperuricemia in a mouse model of renal insufficiency

Objectives: To investigate the role of the intestinal flora and metabolites in the development of hyperuricemic renal injury in chronic kidney disease (CKD).Methods: Unilaterally nephrectomized mice were fed with adenine and potassium oxonate for 9 weeks. HE staining combined with plasma biochemical...

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Principais autores: Ping Liu, Jianli Yang, Meiping Jin, Ping Hu, Yifan Zhu, Yuyan Tang, Yu Chen, Xudong Xu, Haidong He
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2024-12-01
coleção:Renal Failure
Assuntos:
Chronic kidney disease
hyperuricemia
renal injury
gut microbiota
metabolism profiling
Acesso em linha:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387429
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