MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by standard reverse genetics method, so as to verif...

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Autori principali:	Feixia Gao, Tianhan Yang, Xueying Liu, Feifei Xiong, Jian Luo, Yinglei Yi, Jiangfeng Fan, Ze Chen, Wen-Song Tan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-02-01
Serie:	Vaccines
Soggetti:	mirna-192-5p influenza virus np live attenuated influenza vaccine cross-protection
Accesso online:	https://www.mdpi.com/2076-393X/8/1/65
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