Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity

ABSTRACT Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly. We hypothesized that the increased susceptibility...

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Detalhes bibliográficos

Principais autores:	James F. Colbert, Joshua M. Kirsch, Christopher L. Erzen, Christophe J. Langouët-Astrié, Grace E. Thompson, Sarah A. McMurtry, Jennifer M. Kofonow, Charles E. Robertson, Elizabeth J. Kovacs, Ryan C. Sullivan, Joseph A. Hippensteel, Namrata V. Sawant, Nicole J. De Nisco, Bruce D. McCollister, Robert S. Schwartz, Alexander R. Horswill, Daniel N. Frank, Breck A. Duerkop, Eric P. Schmidt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2023-06-01
coleção:	mBio
Assuntos:	aging host-pathogen interaction metagenomics microbiome sepsis
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.00052-23
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