Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy

Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease resulting in muscle atrophy and neurodegeneration, and is the leading genetic cause of infant death. SMA arises when there are homozygous deletion mutations in the human SMN1 gene, leading to a decrease in corre...

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Principais autores:	James J. Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A. Patten, J. Alex Parker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2020-12-01
coleção:	Disease Models & Mechanisms
Assuntos:	caenorhabditis elegans er stress genetics muscle pathology spinal muscular atrophy
Acesso em linha:	http://dmm.biologists.org/content/13/12/dmm041350
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