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Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis

Abstract Background Ischemia reperfusion injury (IRI) has been shown to increase the risk of tumor recurrence after liver surgery. Also, nonalcoholic fatty liver disease (NAFLD) is associated with increased HCC recurrence. ALOX12–12-HETE pathway is activated both in liver IRI and NASH. Also, ALOX12–...

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Principais autores: Faji Yang, Yuheng Zhang, Haozhen Ren, Jinglin Wang, Longcheng Shang, Yang Liu, Wei Zhu, Xiaolei Shi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-12-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Ischemia reperfusion injury
ALOX12
12-HETE
HCC recurrence
GRP31
Acesso em linha:https://doi.org/10.1186/s13046-019-1480-9
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