Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb

We analyzed the thermodynamics of binding of cocaine and several cocaine metabolites to a humanized anti-cocaine mAb (h2E2), which is under development for the treatment of cocaine use disorders, using isothermal titration calorimetry. The calculated equilibrium dissociation (binding) constants were...

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Autors principals:	Terence L. Kirley, Andrew B. Norman
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-12-01
Col·lecció:	Biochemistry and Biophysics Reports
Matèries:	Monoclonal antibody Cocaine and metabolite binding Isothermal titration calorimetry Thermodynamics Ligand affinity
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2405580822001546
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