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Amantadine-based combination therapy of Parkinson’s disease to prevent fluctuation and dyskinesia – experiences from a Parkinson outpatient clinic

BackgroundThe standard therapy of Parkinson’s disease consists in supplementing the depleted dopamine with oral levodopa. The disadvantages of the levodopa monotherapy – comparable to other dopaminergic substances – are the dose-dependent development of dyskinesia in ON-phases, and bradykinesia and...

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Principais autores: Christian Oehlwein, Lucas Netzel, Katrin Mittmann, Marita Oehlwein, Walter J. Schulz-Schaeffer
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Aging Neuroscience
Fag:
amantadine
dopamine agonist
dyskinesia
fluctuation
levodopa
MAO type B-inhibitor
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2026.1724003/full
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