Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom

Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a potential antivenom support agent to prevent PLA2-dependent effects produced by snake venoms. In this study, we examined the ac...

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Principais autores:	Pamella G. Gutierres, Diego R. Pereira, Nataly L. Vieira, Lilian F. Arantes, Nelson J. Silva, Kristian A. Torres-Bonilla, Stephen Hyslop, Karen Morais-Zani, Rosa M. B. Nogueira, Edward G. Rowan, Rafael S. Floriano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	Viperidae snake phospholipase A2 (PLA2) coagulating activity haemorrhage varespladib antivenom
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2021.812295/full
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