Engineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces
Abstract Base editing (BE) faces protospacer adjacent motif (PAM) constraints and off-target effects in both eukaryotes and prokaryotes. For Streptomyces, renowned as one of the most prolific bacterial producers of antibiotics, the challenges are more pronounced due to its diverse genomic content an...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2024-07-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-024-49987-3 |
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