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Oral Metallo-Beta-Lactamase Protects the Gut Microbiome From Carbapenem-Mediated Damage and Reduces Propagation of Antibiotic Resistance in Pigs

Antibiotics can damage the gut microbiome, leading to serious adventitious infections and emergence of antibiotic resistant pathogens. Antibiotic inactivation in the GI tract represents a strategy to protect colonic microbiota integrity and reduce antibiotic resistance. Clinical utility of this appr...

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Principais autores: Sheila Connelly, Brian Fanelli, Nur A. Hasan, Rita R. Colwell, Michael Kaleko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-02-01
Serier:Frontiers in Microbiology
Fag:
beta-lactamase
antibiotic resistance
gut microbiome
dysbiosis
porcine (pig) model
Online adgang:https://www.frontiersin.org/article/10.3389/fmicb.2019.00101/full
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