Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Tumor necrosis factor alpha (TNF-α) plays a vital role in Alzheimer’s disease (AD) pathology, and TNF-α inhibitors (TNFIs) modulate AD pathology. We fused the TNF-α receptor (TNFR), a biologic TNFI that sequesters TNF-α, to a transferrin receptor antibody (TfRMAb) to deliver the TNFI into the brain...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V. Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H. Cribbs, Rachita K. Sumbria
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2022-10-01
סדרה:	Pharmaceutics
נושאים:	Alzheimer’s disease transferrin receptor TNF-α inhibitor blood–brain barrier molecular Trojan horse
גישה מקוונת:	https://www.mdpi.com/1999-4923/14/10/2200
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!