Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17

11β-Methyl-19-nortestosterone dodecylcarbonate (11β-MNTDC) is a prodrug of 11β-MNT and is being considered as a promising male oral contraceptive candidate in clinical development. However, the oral administration of 11β-MNTDC exhibits an ~200-fold lower serum concentration of 11β-MNT compared to 11...

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Autors principals:	Namrata Bachhav, Dilip Kumar Singh, Diana L. Blithe, Min S. Lee, Bhagwat Prasad
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-08-01
Col·lecció:	Pharmaceutics
Matèries:	biotransformation 11β-Methyl-19-nortestosterone 11β-MNT 11β-MNTDC UGT2B17 oral male contraceptive
Accés en línia:	https://www.mdpi.com/1999-4923/16/8/1032
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